| Ameristar Casino Vicksburg | Vicksburg | Warren | Mississippi | Lower River Region | | |
| Bally’s Vicksburg | Vicksburg | Warren | Mississippi | Lower River Region | | Formerly Rainbow Casino, Lady Luck Casino Vicksburg, and Casino Vicksburg |
| Bayou Caddy’s Jubilee Casino | Greenville | Washington | Mississippi | Lower River Region | | Closed 2012, merged into Trop Casino Greenville[1] |
| Beau Rivage | Biloxi | Harrison | Mississippi | Gulf Coast | | |
| Bok Homa Casino | Sandersville | Jones | Mississippi | | Native American | |
| Boomtown Biloxi | Biloxi | Harrison | Mississippi | Gulf Coast | | |
| Casino Magic Biloxi | Biloxi | Harrison | Mississippi | Gulf Coast | | Closed 2005 |
| Copa Casino | Gulfport | Harrison | Mississippi | Gulf Coast | | Closed 2005. Replaced by Island View Casino[2] |
| 1st Jackpot Casino Tunica | Tunica Resorts | Tunica | Mississippi | Upper River Region | | Formerly Bally’s |
| Fitzgeralds Casino Tunica | Tunica Resorts | Tunica | Mississippi | Upper River Region | | |
| Gold Strike Tunica | Tunica Resorts | Tunica | Mississippi | Upper River Region | | |
| Golden Moon Casino | Choctaw | Neshoba | Mississippi | | Native American | Part of the Pearl River Resort |
| Golden Nugget Biloxi | Biloxi | Harrison | Mississippi | Gulf Coast | | |
| Grand Station Casino | Vicksburg | Warren | Mississippi | Lower River Region | | Closed 2012[3] |
| Hard Rock Hotel & Casino Biloxi | Biloxi | Harrison | Mississippi | Gulf Coast | | |
| Harlow’s Casino | Greenville | Washington | Mississippi | Lower River Region | | |
| Harrah’s Casino Tunica | Tunica Resorts | Tunica | Mississippi | Upper River Region | | Formerly Grand Casino Tunica; closed 2014 |
| Harrah’s Gulf Coast | Biloxi | Harrison | Mississippi | Gulf Coast | | |
| Hollywood Casino Gulf Coast | Bay St. Louis | Hancock | Mississippi | Gulf Coast | | Formerly Casino Magic |
| Hollywood Casino Tunica | Tunica Resorts | Tunica | Mississippi | Upper River Region | | |
| Horseshoe Casino Tunica | Tunica Resorts | Tunica | Mississippi | Upper River Region | | |
| IP Casino Resort Spa | Biloxi | Harrison | Mississippi | Gulf Coast | | |
| Island View Casino | Gulfport | Harrison | Mississippi | Gulf Coast | | |
| Isle of Capri Casino Hotel Lula | Lula | Coahoma | Mississippi | Upper River Region | | |
| Isle of Capri Casino Hotel Natchez | Natchez | Adams | Mississippi | Lower River Region | | Closed 2015[4] |
| Magnolia Bluffs Casino | Natchez | Adams | Mississippi | Lower River Region | | |
| Margaritaville Casino and Restaurant | Biloxi | Harrison | Mississippi | Gulf Coast | | Closed 2014 |
| Palace Casino Biloxi | Biloxi | Harrison | Mississippi | Gulf Coast | | |
| President Casino Broadwater Resort | Biloxi | Harrison | Mississippi | Gulf Coast | | Closed 2005 |
| Resorts Casino Tunica | Tunica Resorts | Tunica | Mississippi | Upper River Region | | Closed 2019 |
| Riverwalk Casino and Hotel | Vicksburg | Warren | Mississippi | Lower River Region | | |
| Sam’s Town Hotel and Gambling Hall, Tunica | Tunica Resorts | Tunica | Mississippi | Upper River Region | | |
| Scarlet Pearl Casino | D’Iberville | Harrison | Mississippi | Gulf Coast | | |
| Silver Slipper Casino | Lakeshore | Hancock | Mississippi | Gulf Coast | | |
| Silver Star Casino | Choctaw | Neshoba | Mississippi | | Native American | Part of the Pearl River Resort |
| Treasure Bay Casino Biloxi | Biloxi | Harrison | Mississippi | Gulf Coast | | |
| Trop Casino Greenville | Greenville | Washington | Mississippi | Lower River Region | | Formerly Lighthouse Point Casino |
| Tunica Roadhouse Casino & Hotel | Tunica Resorts | Tunica | Mississippi | Upper River Region | | Formerly Sheraton Casino and Hotel Tunica; casino floor closed 2019, hotel remains in operation |
| WaterView Casino & Hotel | Vicksburg | Warren | Mississippi | Lower River Region | | Formerly Isle of Capri and DiamondJacks |
